Laboratory of the MC “Mother and Child”: in accordance with the latest trends.

The laboratory of the Medical Center “Mother and Child” has been operating since 2018. Has a License from the Ministry of Health of Ukraine. The quality of research performed by the laboratory is confirmed by the results of external quality control with the reference laboratory of the Ministry of Health of Ukraine. The laboratory of the Medical Center has an accreditation certificate according to the national standard DSTU EN ISO 15189:2015 (EN ISO 15189: 2012, IDT) “Medical laboratories - requirements for quality and competence.”

Equipment

It was possible to achieve the current indicators thanks to the professionalism of our employees and modern, high-tech equipment, which allows us to conduct complex genetic and clinical studies. In particular, these are two sequencers (Ion GeneStudio S5 and Seqstudio Genetic Analyzer) for unique molecular examinations and an automated station (Ion Chef), which allows sample preparation for next-generation sequencing NGS.

Possibilities

The laboratory of the MC "Mother and Child" consists of two divisions - clinical diagnostic and genetic. The first includes a full range of general clinical tests, biochemistry, hematology, immunology and cytology. The second, which allows obtaining information at the DNA level, is conducting cytogenetic studies - peripheral blood karyotype for patients and FISH technology using fluorescent tags (sperm FISH/TUNEL for men, preimplantation genetic testing of embryonic tissues for 5 chromosomes).

The molecular genetic division has the technical ability to identify any pathological mutation in parents who are carriers or themselves suffer from a certain genetic disease, and through the use of reproductive technologies to enable such couples to give birth to a healthy child.

This unit of the medical center also conducts genetic screening studies. As an example, the determination of mutations in the cystic fibrosis gene, polymorphisms of hemostasis genes - folate cycle, thrombophilia, determination of microdeletions in the Y chromosome, analysis of the fragile X chromosome (Martin Bell syndrome), phenylketonuria, etc. The equipment in the laboratory allows for pre-implantation genetic screening of embryos for 24 chromosomes using the NGS method.

The laboratory's work includes the most complex genetic studies: identification of mutations in parents (muscular dystrophy, dystroglycanopathy, chondrodysplasia, Duchenne dystrophy, hemophilia, microspherocytosis) and NGS analysis of embryos to determine the presence of these mutations. The list of laboratory capabilities also includes examination of all genes (examination of one’s “genetic passport” and identification of genetic disorders that can lead to hereditary diseases in a child).

GSE (genetic screening of embryos) is indicated primarily:

• women of older reproductive age;
• women with miscarriage (presence of miscarriages, especially in the early stages);
• after unsuccessful IVF attempts;
• existing male factor infertility;
• complicated family history.

Goals for preimplantation genetic testing:

• increase the likelihood of pregnancy;
• reduce the risk of spontaneous miscarriage;
• reduce the incidence of multiple pregnancies;
• prevent and reduce the incidence of congenital malformations.

In addition to patients, other reproductive clinics that do not have such equipment will be able to receive research assistance.

Full address: 04114, Ukraine, Kyiv, st. Makeevskaya, 8 (genetic department)